Best Probiotics for Weight Loss

As the scientific study of probiotics progresses, we’re learning more about the other roles good bacteria play in human health – like weight loss. Studies show that gut bacteria influence our blood sugar levels, our appetite and other things that can contribute to weight gain, and by that token, getting and maintaining healthy levels of good gut bacteria can actually help you lose weight. By taking a good quality probiotic supplement not only are you helping your immune system (80% of which is in your gut), you’re also taking the right steps to fight weight gain caused by a lack of healthy gut bacteria.

The benefits of probiotics to losing weight

probiotics for weight lossDiet, stress, antibiotics and illnesses both chronic and acute can all wreak havoc on your gut, killing the good bacteria. The only way to fix this situation is to introduce more good bacteria to your gut.

The biggest benefit of probiotics for weight loss is that supplemental probiotics give your gut enough good bacteria to replenish its population and reach a level required for overall general health. Getting your good bacteria levels to this point is crucial for reaping the weight loss benefits of probiotics.

There are a lot of studies that talk about how our gut bacteria affects our weight. One of the most dramatic examples of this is the story of the mother who underwent a fecal matter transplant (FMT – and yes, it is what it sounds like) with her daughter as the donor. Afterward, the mother, who had always been thin, started rapidly gaining weight for seemingly no reason. The long story short is that her daughter who was her donor was overweight at the time she made the donation and therefore her gut bacteria – though it saved her mother’s overall health – had the side effect of causing her mother to gain weight. It is examples like this that have caused scientists to take a hard look at the roles good bacteria – and probiotics – play in weight loss.

To understand the science behind why bad gut bacteria can make us gain weight, we have to remember that bacteria are living creatures that live inside of us. In 2016, a reevaluation of old estimates was done, but the bottom line is that there are indeed more bacteria cells in the human body than there are human cells in the human body, generally. But on average, a person has about 39 trillion bacteria cells and only 30 trillion human cells. And that ratio can dramatically shift depending on how often you go #2. Women likely have far more bacteria to human cells than men do, because they’re smaller on average and just have less human cells as a result.

So, what does the above tell us? Quite simply that we have a ton of bacteria in our bodies. Can you imagine how catastrophic it would be if you had far more bad bacteria than good bacteria in your gut, when you realize just how many bacteria in general there are? That is why maintaining a healthy balance of gut bacteria – also known as microflora – is absolutely essential for your health.

Going back to the mother-daughter FMT story, what that story tells us is that some overweight people are carriers of bad bacteria that cause them to gain weight – and that bacteria can be transplanted into another person, causing to gain weight too.


Top Probiotics for Weight Loss Review


1. Hyperbiotics PRO-15 Probiotics


Patented delivery system

Hyperbiotics PRO-15 has their own patented delivery system, which allows 60% of the probiotics in each probiotic pearl survive to make it past your stomach acid; this is in contrast to the standard plain capsules of other brands, which yield only a 4% survival rate. The key is their special LiveBac manufacturing process which works in tandem with the Hyperbiotics delivery technology called BIO-tract. It’s a gel matrix that provides a superior seal to protect the probiotics inside both on the store shelf before they’re sold, but also once you take one. BIO-tract is able to keep 60% of the probiotics alive where they can go to work not only in your small intestine, but your large one is well – something most probiotics simply aren’t able to do. Additionally, unlike other probiotics, Hyperbiotics PRO-15 slowly releases in your body over an 8 to 10-hour period, which is not only gentler on the stomach, but it helps ensure the good bacteria inside colonizes your gut.

15 probiotic strains

A lot of infections that require antibiotic treatment nowadays are resistant to the old, narrow spectrum antibiotics of the past and require broad spectrum antibiotics. And while broad spectrum antibiotics are lifesavers, they can also destroy the microbiome of your gut, allowing bad bacteria to flourish. Your gut bacteria population is made up of many different strains in a healthy gut; the 15 probiotic strains in PRO-15 seeks to add biodiversity to your gut flora; as anyone who knows a little thing or two about biology knows, biodiversity is crucial to the health of all life on earth – and the same is true for the bacteria in your gut.

5 billion colony forming units (CFUS)

The high survival rate of the probiotics in Hyperbiotics pearls ensure that 5 billion of their colony forming units is the equivalent of 75 billion colony forming units in other brands, proving their superior efficacy.

Includes a built-in prebiotic

Prebiotic fiber is what feeds good bacteria. A diet low in fiber is a big part of what contributes to a lack of healthy bacteria in your gut. Hyperbiotics PRO-15 solves this problem by putting your probiotic’s food right inside the pearl with it, so the prebiotics feed the probiotics while they go to work in our gut.

Long shelf life

The patented BIO-tract gel matrix coating keeps out heat and moisture and ensure a long shelf life (18 months) without the need for refrigeration.

  • Made in the USA: Tablets are produced in a GMP-certified facility; additionally, the company adheres to FDA guidelines.
  • 15 proven strains of good bacteria
  • Prebiotics included for improved healthy gut flora
  • 18-month shelf life
  • No need to refrigerate
  • Easy on the stomach thanks to time release action
  • All natural
  • Easy to swallow
  • Dose is only one pearl a day
  • Helps boost metabolism
  • As with all probiotics, you may experience minor gas when you first start PRO-15; however, this is super rare and goes away as soon as your body adjusts to it.


2. Number One Nutrition Probiotic Supplement


Shelf stable before opening

Number One Nutrition Probiotic Supplement is shelf stable, meaning that it doesn’t require refrigeration to be effective – before it’s opened, though it is required you refrigerate it afterward.

7 probiotic strains

There are 7 probiotic strains – all well known and effective – included species of Bacillus, Lactobacillus and Bifidobacterium. This level of probiotic diversity ups the odds that your guts receive the precise probiotic they need to get healthier.

Contains prebiotic

Number One’s probiotic includes a prebiotic in the mix to feed the healthy bacteria once it enters your gut. This not only helps the good flora survive—it also helps them thrive and multiply.

Survives the stomach

Number One Probiotic Supplement is designed to survive stomach acid to deliver the probiotics where you need them the most – your gut.

  • Made in the USA: The facility the company uses is also FDA-approved
  • Doesn’t require refrigeration prior to opening
  • 7 probiotic strains
  • Contains prebiotic
  • Survives stomach acid
  • Must be refrigerated after opening: This isn’t that convenient, but if you aren’t somebody who travels a lot – and owns a fridge – it’s not too much of a big deal when it comes to bettering your health.
  • Must be taken twice a day: This is a con that’s only a big deal if you’re super busy; for most, this likely won’t be an issue, but is worth mentioning.


3. PRO-Women: Probiotics with Cranberry Extract & D-Mannose


6 targeted and effective probiotic strains

All 6 of the targeted strains – species of Lactobacillus and Bifidobacterium – are proven to be effective against stomach, metabolism and general health issues.

Contains prebiotic

Prebiotic is the food probiotics require to thrive and multiply, which is why Hyperbiotics added them to their PRO-Women probiotic mix.

Urinary tract support

It adds cranberry extract and naturally-occurring (non-synthetic) D-Mannose to the mix to create a probiotic that also benefits those with UTIs.

15 times more effective than competitors

Thanks to the patented BIO-Tract gel matrix coating, PRO-Women’s good bacteria survive 15 times more than competitors.

No refrigeration required

There is no required refrigeration before or after opening.

  • Made in the USA: GMP-certified; follows FDA guidelines
  • Probiotics designed specifically for women with UTI and yeast issues
  • Doesn’t require refrigeration – even after opening
  • 15 times more good bacteria survival than competitors
  • 6 proven and effective strains
  • Includes Lactobacillus and Bifidobacterium strains
  • One pearl tablet is a full day’s dose
  • It has less strains than its sister probiotic mix, PRO-15, though this is more of a nit-pick than a huge deal.
  • Contains cranberry, which, while great for UTIs (lower down in the urinary tract), isn’t the best for those with kidney issues.


4. BIOPRO-50 Probiotic


11 well-known strains

11 well-known strains of bacteria, including those belonging to the Bacillus, Lactobacillus and Bifidobacterium families, lend biodiversity to your gut.


BIOPRO-50 contains prebiotic to help the probiotics colonize your gut.

Special diet-friendly

BIOPRO-50 is dairy-free, gluten-free and raw vegan, so even if you follow a special diet, BIOPRO-50 has you covered.

  • Made in the USA: FDA and GMP-certified
  • 11 strains provide biodiversity in your gut
  • No refrigeration needed
  • Easy to swallow
  • Vegan, dairy-free, gluten-free
  • The main issue with BIOPRO-50 is that many feel it just “doesn’t work” or isn’t on par with probiotics with similar specs.


5. ProbioSlim Probiotics + Weight Loss Supplement


Green tea complex

The EGCG in the green tea complex that’s part of the ProbioSlim Probiotics mix is purported to help you burn fat faster than you would without it.


The caffeine in ProbioSlim boosts the natural, healthy-gut energy that only probiotics can give.

Contains LactoSpore

LactoSpore is a probiotic that not only decreases belly bloat, but can also more readily survive stomach acid.

Kiwi prebiotic

The prebiotic in ProbioSlim is naturally derived from Kiwi fruit.

  • Naturally derived ingredients
  • Green tea component for metabolism boost
  • LactoSpore reputed to survive stomach acid well
  • Contains the herb Butcher’s Broom: While Butcher’s Broom is safe for healthy individuals, it is a stimulant and interacts with other stimulants, as well as medication or high blood pressure. It may also upset your stomach.
  • The caffeine in ProbioSlim could make you jittery – especially when combined with Butcher’s Broom.
  • Doesn’t appear to burn fat – though it may help with the probiotic end of the weight issue.



At the end of the day, the clear winner of this best probiotic for weight loss roundup is easily Hyperbiotics PRO-15 Probiotics. Not only do they have the most biodiversity in their strains, they also have the best technology behind their delivery system, ensuring you get those strains. After all, the whole point of probiotics for weight loss is to change your gut flora balance back to one that contains a rich diversity of healthy bacteria – and Hyperbiotics PRO-15 Probiotics delivers on that without gimmicks and unnecessary addons.

Why does the bad bacteria cause people to gain weight in the first place?

bad gut bacteriaIt’s important to remember that the science behind gut bacteria is very young, but the big two reasons bad gut flora can make you fat are thought to be:

  1. Bad gut bacteria can cause a rise in blood sugar prompting you to feel hungry more often and eat more without realizing it.
  2. Bad gut bacteria affect the way your body responds to the “hunger hormones” leptin and ghrelin. Leptin normally tells you that you’re full when you’re done eating, suppressing your appetite; it’s thought that bad bacteria numbs this response. As for ghrelin – it’s the appetite hormone that causes you to eat more; it’s thought that bad gut bacteria overstimulate ghrelin causing you to be hungry all the time.

In regard to leptin, newer research indicates that many overweight and obese people are “leptin-resistant”, meaning their bodies and brains just aren’t responding to the “I’m full” signal that leptin should be sending to them, thus they can’t naturally control their calorie intake. And one of the primary causes of leptin-resistance is thought to be the unhealthy mix of bad gut bacteria most overweight people have in their guts.

The only way to combat all of the above issues is to take a probiotic supplement with proven beneficial strains of healthy gut bacteria to replenish the population of good bacteria you’ve lost, which will in turn kill off the overgrowth of bad gut bacteria that happens when there’s not any good bacteria in your system to stop the bad bacteria from wreaking havoc on your body.

How to choose the best probiotics for weight loss

There are a few things to keep in mind when looking for the best probiotics for your needs. Consider the following:

  • Go for a probiotic made in the US – they are required by law not to put out anything dangerous when taken as directed
  • Choose a probiotic with multiple strains to improve the biodiversity in your microbiome (where the good gut flora live)
  • Optionally, you can also go for female or male-oriented probiotics with specific qualities suitable for each gender
  • Avoid products and body detox recipes with unnecessary ingredients, they don’t help you lose weight the way probiotics do and can actually harm your health
  • Make sure to check the ingredients of any colon cleansing products you are using, they might already contain probiotics.
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